Neutrophil CD177 (NB1 gp, HNA-2a) expression is increased in severe bacterial infections and polycythaemia vera
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چکیده
منابع مشابه
Molecular basis of NB1 (HNA-2a, CD177) deficiency.
Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in immune neutropenia and transfusion-related acute lung injury. Recently, we were able to elucidate the primary structure of NB1. To shed light also on the molecular basis of the NB1-negative phenotype, we studied the neutrophils of 2 women with NB1-specific alloantibodies for intracellular and extracellular NB1 expressi...
متن کاملBrief report Molecular basis of NB1 (HNA-2a, CD177) deficiency
Alloimmunization to the neutrophil antigen NB1 (HNA-2a, CD177) can result in immune neutropenia and transfusionrelated acute lung injury. Recently, we were able to elucidate the primary structure of NB1. To shed light also on the molecular basis of the NB1-negative phenotype, we studied the neutrophils of 2 women with NB1-specific alloantibodies for intracellular and extracellular NB1 expressio...
متن کاملTRANSFUSION MEDICINE Brief report Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP neutrophils from NB1 GP–expressing individuals and association of low expression with NB1 gene polymorphisms
The human neutrophil NB1 glycoprotein (NB1 GP, HNA-2a, CD177) has gained clinical importance for being involved in pulmonary transfusion reactions and immune neutropenias. The NB1 GP shows the unique feature of being expressed only on a neutrophil subpopulation. Recently, we identified splicing defects responsible for an NB1 GP deficiency. In this study, we have investigated the molecular basis...
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Polycythaemia vera (PV) can be defined as a myeloproliferative neoplasm (MPN) with erythrocytosis and JAK2V617F (or an equivalent marker of clonality). While these simple criteria are sufficient for most cases of overt PV, an estimated 10–15% of PV patients do not have an elevated haemoglobin concentration (Hb) and may mimic JAK2-positive essential thrombocythaemia (ET). This poses a problem fo...
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well account for the phonocardiographic features of extreme variability of the A2-OC interval and the intermittent absence of the OC. The systolic murmur was in keeping with mitral reflux with its rate related variability. In a very ill patient with a malfunctioning mitral Starr-Edwards prosthesis we feel that the phonocardiographic findings can be a useful bedside adjunct to the physician and ...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2004
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2004.05027.x